naftifiine

Naftifine is a synthetic antifungal medication belonging to the allylamine class. It is primarily used topically to treat fungal infections of the skin, such as ringworm, athlete's foot, and jock itch. Its mechanism of action involves inhibiting squalene epoxidase, a key enzyme in the fungal cell membrane biosynthesis pathway. This inhibition leads to a deficiency in ergosterol, the primary sterol in fungal cell membranes, and an accumulation of squalene, which is toxic to the fungus.

Naftifine is available in various formulations, including creams, gels, and solutions. It is applied directly to the affected skin area, usually once or twice daily, for a prescribed duration. The typical treatment course can range from two to four weeks, depending on the severity and type of infection. Common side effects are generally mild and localized, such as itching, redness, burning, or dryness at the application site. Systemic absorption is minimal, making it a safe option for most individuals. It is important to complete the full course of treatment even if symptoms improve to prevent recurrence. Naftifine is not typically used for nail or scalp fungal infections.