mykophenolaatti

Mykophenolate mofetil, commonly known as mykophenolate, is an immunosuppressant medication used to prevent organ rejection in patients who have received organ transplants. It is also used to treat certain autoimmune diseases, such as lupus and rheumatoid arthritis. Mykophenolate works by inhibiting the production of certain immune cells, thereby reducing the body's immune response.

The medication is available in tablet form and is typically taken orally. It is usually prescribed in combination with other immunosuppressants to achieve optimal therapeutic effects. Mykophenolate is generally well-tolerated, but like all medications, it can cause side effects. Common side effects include nausea, vomiting, diarrhea, and abdominal pain. More serious side effects, although rare, can include liver toxicity and an increased risk of infections.

Mykophenolate is a prodrug, meaning it is converted into its active form, mykophenolic acid, in the body. The active form inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the synthesis of guanine nucleotides, which are essential for the proliferation of T and B lymphocytes. By inhibiting IMPDH, mykophenolate reduces the production of these immune cells, thereby suppressing the immune response.

Mykophenolate is not recommended for use in patients with a history of liver disease or those who are allergic to the medication. It is also contraindicated in patients with a history of bone marrow suppression or those who are pregnant or breastfeeding. As with any medication, it is important to follow the prescribed dosage and to discuss any concerns or side effects with a healthcare provider.