mescalinecontaining

Mescaline-containing substances refer to natural or synthetic materials that include the psychoactive alkaloid mescaline. The best known natural sources are certain cacti, most notably the peyote cactus (Lophophora williamsii) and various echinopsis species such as San Pedro (Echinopsis pachanoi) and Peruvian torch (Echinopsis peruviana). Related cacti in the Trichocereus group also contain mescaline to varying degrees. In addition to cacti, small amounts have been reported in a few other plants, but cacti account for the majority of documented mescaline use.

Chemically, mescaline is 3,4,5-trimethoxyphenethylamine. It acts primarily as an agonist at serotonin 5-HT2A receptors, producing alterations in perception, mood, and cognition. Typical effects include visual and auditory enhancements, vivid imagery, changes in thought patterns, and a sense of spiritual or transcendent experience for some users. Onset is usually within one to two hours after ingestion, with effects lasting roughly eight to twelve hours. Common side effects include nausea and vomiting (especially with peyote), as well as increased heart rate, blood pressure, and pupil dilation. Risks can include anxiety, confusion, and, in predisposed individuals, triggering of psychotic-like symptoms. Interactions with monoamine oxidase inhibitors or other serotonergic drugs can intensify effects or raise the risk of adverse reactions.

Legal status varies by jurisdiction. In many countries, mescaline is controlled or illegal to possess, manufacture, or distribute. In the United States, mescaline is a Schedule I substance, though there is an exemption allowing use of peyote in Native American religious ceremonies. Other regions impose similar prohibitions, while some jurisdictions provide limited research exemptions or ceremonial allowances. Safety, legality, and ethical considerations are important when discussing mescaline-containing substances.