mac1
Mac-1, also known as macrophage-1 antigen, is a cell-surface receptor that belongs to the integrin alpha chain family. In humans it is the αMβ2 integrin, formed by the αM chain (CD11b, encoded by ITGAM) and the β2 chain (CD18, encoded by ITGB2). Mac-1 is prominently expressed on myeloid lineage cells, including neutrophils, monocytes, macrophages, some dendritic cells, and certain natural killer cells. As a heterodimer, Mac-1 mediates both adhesion and recognition functions critical to innate immunity.
Mac-1 mediates firm adhesion of leukocytes to endothelial cells by binding to intercellular adhesion molecule 1
Activation of Mac-1 is regulated by inside-out signaling, which increases its affinity for ligands in response
Clinical interest centers on modulating Mac-1 activity to control leukocyte recruitment in inflammatory and autoimmune diseases.