Mac1ICAM
Mac1ICAM refers to the functional adhesion interface formed between the leukocyte integrin Mac-1 and ICAM family ligands, most notably ICAM-1, during immune cell trafficking. It is not a separate protein unit, but the binding interaction that mediates stable adhesion of leukocytes to endothelial cells and subsequent transmigration during inflammatory responses.
Mac-1 is the integrin αMβ2, comprised of the CD11b (αM) and CD18 (β2) subunits. The ligand-binding site
Regulation of Mac-1ICAM binding involves cytoplasmic adaptor proteins such as talin and kindlin-3, which promote activation
Biological roles include mediating neutrophil and monocyte firm adhesion to activated endothelium, supporting diapedesis, and contributing