log10PKKo

Log10PKKo is a term used in pharmacokinetics, the study of how drugs are absorbed, distributed, metabolized, and excreted by the body. It is a measure of the extent to which a drug is bound to plasma proteins, specifically to the alpha-1-acid glycoprotein (AAG) or albumin, in the blood. PKKo stands for the concentration of the unbound drug in plasma, while PKK is the concentration of the bound drug. The ratio PKKo/PKK is a measure of the binding affinity of the drug to the protein. Log10PKKo is simply the base-10 logarithm of this ratio, which is often used to express the binding affinity in a more convenient range of values. A higher log10PKKo value indicates stronger binding of the drug to the protein. This parameter is important in pharmacology and drug development, as it can influence the drug's pharmacodynamic effects, distribution, and elimination from the body. It is typically determined using equilibrium dialysis or other binding assays.