lisinopriil
Lisinopriil, usually written lisinopril, is an oral angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure. It is also prescribed after acute myocardial infarction to improve survival and to slow the progression of kidney disease in diabetes.
Mechanism of action: Lisinopril inhibits ACE, decreasing conversion of angiotensin I to angiotensin II and reducing
Pharmacokinetics: Lisinopril is not a prodrug; it is active on administration. It is modestly absorbed from
Clinical use: Hypertension, symptomatic heart failure, and post–myocardial infarction management. It may be used to protect
Adverse effects and safety: Common adverse effects include dizziness, cough, and hyperkalemia. Angioedema is a rare
History and availability: Lisinopril was first approved in 1991. Brand names include Zestril and Prinivil; generic