linkerDNAlængde
LinkerDNAlængde refers to the length of linker DNA, the stretch of DNA that connects adjacent nucleosomes in the chromatin fiber. Each nucleosome core particle wraps about 147 base pairs of DNA; the linker DNA between cores varies in length among organisms, cell types, and developmental stages.
The nucleosome repeat length (NRL) equals core DNA plus linker DNA, and in many eukaryotes it ranges
Factors influencing linker length include occupancy of histone H1, chromatin remodeling activities, DNA sequence preferences, and
Longer linker DNA generally promotes a more extended 10 nm fiber and can affect transcription factor access,
Measurement approaches include micrococcal nuclease digestion followed by sequencing (MNase-Seq) or gel analysis to determine nucleosome