lharmine

Lharmine is a naturally occurring alkaloid found in certain species of plants, notably *Peganum harmala*, commonly known as Syrian rue. It is one of the primary psychoactive compounds present in this plant, alongside harmaline and harmine. Chemically, lharmine is an indole alkaloid and shares a structural similarity with other beta-carbolines. Its pharmacological effects are primarily attributed to its ability to inhibit monoamine oxidase (MAO), an enzyme responsible for breaking down neurotransmitters like serotonin, dopamine, and norepinephrine. This inhibition can lead to increased levels of these neurotransmitters in the brain. Historically, *Peganum harmala* has been used in traditional medicine and shamanic practices in various cultures. Lharmine, as a component of this plant, has been investigated for its potential therapeutic properties, though research is ongoing and much remains to be understood. It is important to note that the use of lharmine and plants containing it can have significant physiological effects and potential side effects, and should be approached with caution and awareness of its pharmacological profile.