kolistiini
Colistin, also known as polymyxin E, is an antibiotic used to treat severe infections caused by multi-drug resistant Gram-negative bacteria. It belongs to the polymyxin class of antibiotics, which were discovered in the 1940s. Colistin works by disrupting the bacterial cell membrane, leading to cell death. Due to its potential for nephrotoxicity and neurotoxicity, colistin was largely abandoned for systemic use in humans for several decades. However, with the rise of antibiotic-resistant bacteria, it has been reintroduced as a last-resort antibiotic.
Colistin is typically administered intravenously for systemic infections and topically or via inhalation for localized infections.
The increasing prevalence of multidrug-resistant bacteria has led to a resurgence in the use of colistin. However,