ketolides
Ketolides are a class of semi-synthetic macrolide antibiotics developed to address macrolide resistance. They are derived from erythromycin by introducing a ketone-containing modification, typically replacing the cladinose sugar with a C3 ketone, which enhances ribosome binding and activity.
Mechanism of action: Ketolides bind to the 50S subunit of the bacterial ribosome at the peptidyl transferase
Spectrum and clinical use: Ketolides show activity against common respiratory pathogens including Streptococcus pneumoniae, Haemophilus influenzae,
Safety and regulatory status: Telithromycin, the first ketolide, has been associated with rare but serious liver