ketalsfunctional
Ketals are a class of acetal derivatives formed from ketones by replacing the carbonyl oxygen with two alkoxy groups. The general structure is R2C(OR')2, where the two carbon substituents (R groups) come from the original ketone and the OR' groups are alkoxy substituents. Ketals are typically prepared by acid-catalyzed condensation of a ketone with an alcohol or with a diol. When a diol is used, cyclic ketals are formed, such as 1,3-dioxolanes or 1,3-dioxanes; a common example is the cyclic ketal formed from acetone and ethylene glycol, 2,2-dimethyl-1,3-dioxolane, a frequently used protecting group for carbonyls.
Stability and reactivity: Ketals are generally stable to basic conditions and many nucleophiles but are labile
Applications: The primary role of ketals is as protecting groups for carbonyl functionalities, allowing selective reactions
Relation to acetals: Ketals are acetals derived from ketones; acetals derived from aldehydes are also common.