keratocyte

Keratocyte is a type of cell found in the cornea, the transparent front part of the eye. These cells are responsible for maintaining the structural integrity and transparency of the cornea. Keratocytes are derived from mesenchymal stem cells and play a crucial role in wound healing and tissue repair within the cornea. They are characterized by their ability to migrate and proliferate, which is essential for the regeneration of corneal tissue after injury or disease.

Keratocytes are typically located in the stroma, the middle layer of the cornea, where they are surrounded by collagen fibers. These cells are involved in the synthesis and secretion of extracellular matrix components, including collagen and proteoglycans, which contribute to the cornea's structural support and transparency. In addition to their structural roles, keratocytes also have immunomodulatory functions, helping to regulate the inflammatory response in the cornea.

Keratocytes can be affected by various conditions, such as corneal edema, ulcers, and dystrophies. In these cases, the normal function of keratocytes may be impaired, leading to compromised corneal health. Research into keratocyte biology and function is ongoing, with the goal of developing better treatments for corneal diseases and improving overall eye health.