karmustine
Karmustine, also known as BCNU (bis-chloroethylnitrosourea), is a chemotherapy medication used primarily in the treatment of certain cancers. It belongs to the class of alkylating agents, which work by attaching alkyl groups to DNA molecules, thereby disrupting DNA replication and transcription. This mechanism leads to cell death, particularly targeting rapidly dividing cancer cells.
Karmustine has a broad spectrum of activity against several types of tumors, including brain tumors such as
The drug's cytotoxic effects can also impact healthy tissues, leading to side effects such as bone marrow
Karmustine was first developed in the 1950s and has since been incorporated into various chemotherapeutic regimens.
Overall, karmustine plays a key role in oncology, especially for its ability to penetrate the CNS and
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