kalcineuriin
Kalcineuriin, known in English as calcineurin, is a calcium/calmodulin-dependent serine/threonine protein phosphatase that plays a central role in activating T cells and regulating other calcium-sensitive signaling pathways. It functions as a heterodimer composed of a catalytic A subunit and a regulatory B subunit. In mammals, catalytic subunits include PPP3CA, PPP3CB, and PPP3CC, while regulatory subunits include PPP3R1 and PPP3R2. The enzyme is widely expressed and participates in various cellular processes beyond the immune system.
Activation of kalcineuriin depends on rising intracellular calcium levels. Calcium binds calmodulin, which then activates the
Clinical relevance centers on its regulation by immunosuppressants. Cyclosporine A binds to cyclophilin, and tacrolimus (FK506)