inhibitorok
An inhibitor is a substance or process that decreases the rate or extent of a biochemical reaction or metabolic pathway. In biochemistry, inhibitors commonly target enzymes by reducing their catalytic activity. Inhibitors can be reversible, forming non-covalent complexes, or irreversible, often forming covalent bonds with the enzyme. They can also be classified by their mode of action: competitive inhibitors resemble the substrate and bind to the active site; noncompetitive inhibitors bind to an allosteric site independent of substrate binding; uncompetitive inhibitors bind only to the enzyme–substrate complex; mixed inhibitors display properties of more than one class.
Reversible inhibitors may be removed by dilution or dialysis, whereas irreversible inhibitors typically permanently inactivate the
Common examples include pharmacological enzyme inhibitors: ACE inhibitors (such as captopril), statins (HMG-CoA reductase inhibitors), protease
Quantitative properties such as IC50, Ki, and Kd describe inhibitor potency and affinity. Ki measures the affinity