hypocretinism
Hypocretinism refers to conditions characterized by a deficiency or dysfunction of hypocretins, also known as orexins. Hypocretins are neuropeptides produced in the hypothalamus that play a crucial role in regulating sleep-wake cycles, arousal, appetite, and reward pathways.
The most common condition associated with hypocretinism is narcolepsy type 1 (NT1). In NT1, the brain's immune
While narcolepsy type 1 is the primary manifestation of hypocretin deficiency, research suggests that hypocretin dysfunction
Diagnosis of hypocretin deficiency often involves measuring hypocretin levels in cerebrospinal fluid. Treatment strategies for conditions