histonentails
Histonentails are the N- and C-terminal extensions of histone proteins that protrude from the nucleosome core and are subject to a variety of post-translational modifications. The term is used to describe these flexible, intrinsically disordered regions collectively, with differences in length and composition among histone types and variants.
The most studied histonentails belong to histones H3 and H4, though H2A and H2B also possess tail
Modifications on histonentails include acetylation, methylation, phosphorylation, ubiquitination, sumoylation, and newer forms of acylation. Enzymes that
Functionally, histonentails affect nucleosome stability and higher-order chromatin compaction, thereby modulating DNA accessibility for transcription, replication,
Research on histonentails employs chromatin immunoprecipitation, mass spectrometry-based modification mapping, and structural methods. Their intrinsically disordered