gastriin
Gastriin, commonly known as gastrin, is a peptide hormone produced by G cells in the lining of the stomach, primarily in the antrum, with smaller amounts secreted in the duodenum. It exists in several active forms, the most abundant being gastrin-17 (G-17) and gastrin-34 (G-34). Gastrin is released in response to luminal peptides, amino acids, stomach distension, and vagal stimulation.
Gastrin's main actions are to stimulate gastric acid secretion and promote growth of the gastric mucosa. It
Regulation of gastrin involves both stimulatory and inhibitory signals. Acid in the stomach provides negative feedback
Clinical relevant aspects include hypergastrinemia, which can arise from gastrin-secreting tumors (gastrinomas) causing Zollinger-Ellison syndrome, or