fts2

fts2 refers to the gene FAS ligand (FASLG) in humans. This gene encodes a type II transmembrane protein that plays a crucial role in the immune system. The FAS ligand, also known as CD95L or APO-1L, is a protein that binds to the FAS receptor (CD95 or APO-1). This binding event initiates a signaling cascade that can lead to apoptosis, or programmed cell death. The FASLG-FAS pathway is critical for regulating immune responses, particularly in the elimination of activated lymphocytes and the maintenance of immune homeostasis. It is also involved in tissue remodeling and development. Mutations in the FASLG gene have been associated with certain autoimmune disorders, such as ALPS (Autoimmune Lymphoproliferative Syndrome), where the body fails to properly clear self-reactive immune cells. The expression of FASLG is found in various tissues, including activated T cells, natural killer cells, and some non-immune cells. Its dysregulation has been implicated in both immune deficiency and inflammatory conditions.