Lymphoproliferative
Lymphoproliferative is an adjective used in medicine to describe processes that involve the proliferation of lymphocytes, a type of white blood cell involved in the immune response. In clinical use, it often refers to lymphoproliferative disorders, a spectrum of conditions characterized by excessive or abnormal growth of lymphoid cells within lymph nodes, spleen, bone marrow, or other tissues. These can be broadly divided into reactive (benign) and neoplastic (malignant) processes.
Reactive lymphoproliferation occurs in the setting of infections, inflammation, or immune stimulation and is usually polyclonal
Most lymphoproliferative disorders involve B cells, but T-cell and natural killer (NK) cell proliferations also occur.
Diagnosis relies on clinical evaluation, laboratory studies, imaging, and tissue biopsy. Pathology typically uses histology, flow
Management depends on the underlying cause and may range from observation for benign reactive processes to