fibrinogenlike
Fibrinogen-like is a descriptive term used to refer to proteins that contain a domain molecularly related to fibrinogen, the liver-derived plasma glycoprotein essential for blood clot formation. In the human genome, the label is most often encountered in connection with fibrinogen-like protein 1 (FGL1) and fibrinogen-like protein 2 (FGL2). These proteins are not the same as the classical fibrinogen A, B and gamma chains, but they share a fibrinogen-like domain that underlies structural similarity.
FGL1, primarily produced by hepatocytes and secreted into blood, acts as a ligand for LAG-3, an immune
FGL2 is produced by macrophages and dendritic cells and has a distinct role in coagulation. It possesses
Across different species, fibrinogen-like proteins with similar domains have diverse functions in immunity, hemostasis, and tissue