fibriniverkkoa
Fibriniverkkoa is the three-dimensional fibrous mesh formed during blood coagulation that consists primarily of fibrin fibers created from fibrinogen by thrombin. The network provides structural stability to a forming clot and acts as a scaffold for cellular elements involved in repair.
Formation: After vascular injury, thrombin cleaves fibrinogen to fibrin monomers, which spontaneously polymerize into protofibrils and
Structure and properties: The network’s pore size, fiber thickness, and branching pattern determine clot stability and
Function: The fibrin network stops bleeding by providing a stable matrix and acts as a provisional extracellular
Degradation and remodeling: Fibrinolysis breaks down fibrin with plasmin, initiated by tissue plasminogen activator and plasminogen.
Clinical and research relevance: Understanding fibriniverkkoa aids in interpreting coagulation tests and informs treatment strategies, including