fibrini

Fibrini is a term that may be used to describe fibrin, the insoluble fibrous protein that forms the mesh of a blood clot. Fibrin is derived from fibrinogen, a soluble plasma glycoprotein produced by the liver. During coagulation, thrombin cleaves fibrinogen to form fibrin monomers, which polymerize and are stabilized by factor XIIIa cross-linking to create an insoluble fibrin network.

This network traps platelets and red blood cells, producing a stable clot that seals sites of vascular injury. The structure is a fiber network with branching fibrils that vary in thickness and porosity, enabling both mechanical stability and selective permeability.

Fibrinolysis dissolves clots; plasmin cleaves fibrin to degradation products, including D-dimer, used clinically to assess clot activity. Abnormalities in fibrin formation or breakdown can contribute to disease. Insufficient fibrin formation or function leads to bleeding, while excessive fibrin deposition contributes to thrombosis or microvascular occlusion; disordered fibrin deposition occurs in disseminated intravascular coagulation (DIC).

Fibrin-based sealants are used in surgery to promote hemostasis and tissue adhesion. In diagnostics, clinicians measure fibrinogen levels and D-dimer to assess coagulation status and thrombotic risk.

Note: fibrini is not a standard term in English; in some languages it may be used as the plural form of fibrin.