ferlinlike
Ferlinlike is an informal term used in genomics and protein annotation to describe proteins that resemble ferlins in sequence and domain architecture but are not necessarily classified within the canonical ferlin family. The ferlin family comprises large, multi-domain, transmembrane proteins best known for roles in calcium-dependent membrane fusion and repair, with examples including dysferlin, myoferlin, otoferlin, and the C. elegans fer-1.
Ferlinlike proteins typically feature several C2 domains, a DysF-like domain, and a single C-terminal transmembrane segment.
Distribution across life forms varies; ferlinlike proteins have been identified in a range of taxa, including
Distinguishing features are primarily phylogenetic and architectural: ferlinlike proteins cluster near ferlin sequences but may lack