fatderived

Fatderived is a general term used to describe materials, cells, or products that originate from adipose tissue, the body's fat tissue. In medical and scientific contexts, fat-derived items are studied for regenerative medicine, cosmetic procedures, and tissue engineering. The most common reference is to adipose-derived stem cells, which are multipotent cells recovered from fat tissue.

Adipose-derived stem cells (ADSCs) can differentiate into multiple lineages, including adipogenic, osteogenic, chondrogenic, myogenic, and neural-like cells. They are typically obtained from fat tissue via liposuction and, in some protocols, through enzymatic digestion to yield the stromal vascular fraction (SVF), a mixed population that includes ADSCs, endothelial cells, pericytes, and immune cells. SVF and cultured ADSCs are used in experimental and clinical approaches aimed at promoting tissue repair and reducing inflammation.

Fat-derived grafts, or lipofilling, involve transplanting a patient’s own fat to augment or reconstruct soft tissues. ADSCs or SVF may be added to fat grafts to improve viability and integration, though processing methods and regulatory status vary by jurisdiction.

In addition to cells, researchers study fat-derived extracellular vesicles and exosomes, which are small particles released by adipose tissue or ADSCs and are investigated for their potential regenerative and anti-inflammatory properties.

Regulatory and safety considerations vary globally. Autologous fat-derived procedures are common in cosmetic surgery, while ADSC- and SVF-based therapies are subject to ongoing research and evolving oversight. As with all cell-based therapies, risks include infection, uneven graft outcomes, and, in some cases, tumorigenic concerns, necessitating careful clinical evaluation and standardized processing.