epigenomegenome
Epigenomegenome is a term used to describe an integrated view that combines an organism's genome sequence with its epigenome—the collection of chemical modifications and chromatin features that regulate gene expression without altering the DNA sequence. The genome provides the primary genetic blueprint; the epigenome modulates when, where, and how this blueprint is read in a tissue- and time-specific manner.
Epigenetic marks include DNA methylation, histone modifications, chromatin accessibility, and higher-order genome organization. These features are
Applications span cancer epigenetics, developmental biology, aging research, and precision medicine. Epigenome-genome data underpin epigenome-wide association