eIF4EeIF4GeIF4A
eIF4EeIF4GeIF4A refers to a complex of three eukaryotic initiation factors crucial for the initiation of protein translation. This complex, often referred to as the eIF4F complex, plays a central role in the cap-dependent translation of most eukaryotic messenger RNAs (mRNAs).
eIF4E, also known as the cap-binding protein, is the key component that recognizes and binds to the
eIF4G is a large scaffolding protein that interacts with both eIF4E and eIF4A, as well as other
eIF4A is a DEAD-box RNA helicase that unwinds secondary structures in the 5' untranslated region (UTR) of
The coordinated action of eIF4E, eIF4G, and eIF4A within the eIF4F complex is a highly regulated step