dubbelstrengsbreuk
Dubbelstrengsbreuk, also known as double-strand break (DSB), refers to a type of DNA damage where both strands of the DNA double helix are severed simultaneously. This form of DNA damage can occur due to various factors, including ionizing radiation, certain chemicals, or cellular processes such as replication stress. Because the integrity of the genetic information is compromised, dubbelstrengsbreuk poses a significant threat to cell survival and genetic stability.
The repair of dubbelstrengsbreuk is critical for maintaining genomic integrity and is primarily achieved through two
Cells have evolved sophisticated mechanisms to detect and respond to DSBs, including signaling pathways that activate
Understanding the mechanisms behind dubbelstrengsbreuk and its repair processes is vital in areas such as cancer