doxorubicinepirubicin
Doxorubicin, also known as adriamycin, is a widely used anthracycline antibiotic derived from Streptomyces peucetius var. caesius. It is a potent cytotoxic agent that inhibits topoisomerase II, an enzyme involved in DNA replication and transcription. Doxorubicin is commonly used in the treatment of various types of cancer, including breast, ovarian, and lung cancers, as well as certain types of leukemia. It works by intercalating between the base pairs of DNA, preventing the separation of the two strands during replication, which ultimately leads to cell death.
Doxorubicin is administered intravenously and has a relatively short half-life, requiring frequent dosing. It is known
The drug was first isolated in 1969 and has since been a cornerstone in cancer chemotherapy. Its