desmogleinmediated
Desmoglein-mediated refers to the biological processes governed by the desmoglein family of cadherin proteins that are components of desmosomes. Desmogleins, including desmoglein-1, -2, -3, and -4, mediate calcium-dependent cell–cell adhesion in epithelial and other tissues and participate in signaling pathways that influence keratinocyte behavior, tissue integrity, and wound responses.
Desmogleins are expressed in stratified epithelia with distinct patterns: desmoglein-1 is abundant in the upper epidermal
In pathology, desmoglein-mediated processes are central to autoimmune diseases such as pemphigus. Autoantibodies against desmoglein-1 and
Clinically, desmoglein-mediated autoimmunity manifests as mucocutaneous blisters and erosions in pemphigus forms. Diagnosis relies on serology