deltaNp63

deltaNp63 is a prominent splice variant of the p63 gene, a member of the p53 family of transcription factors. Unlike the full-length p63 isoforms, deltaNp63 lacks the transactivation domain (TA) that is crucial for inducing gene expression. This absence significantly alters its transcriptional activity, often leading to dominant-negative effects or acting as a transcriptional repressor. The deltaNp63 protein is expressed in various tissues, particularly in epithelial cells. It plays a critical role in development and differentiation, especially in the epidermis and its appendages. Its dysregulation has been implicated in the development and progression of several cancers. For instance, elevated levels of deltaNp63 are frequently observed in squamous cell carcinomas, where it can promote proliferation and inhibit apoptosis, contributing to tumor growth and resistance to therapy. Research into deltaNp63 continues to explore its precise molecular mechanisms and its potential as a therapeutic target in cancer treatment.