degranulaatiossa
Degranulatio is a biological process primarily associated with immune cells, particularly mast cells, basophils, and certain types of dendritic cells. During degranulation, these cells release the contents of their intracellular granules—prepackaged vesicles filled with bioactive molecules—into the extracellular space. This process is a key component of the immune response, especially in allergic reactions and inflammation.
Mast cells and basophils store granules containing histamine, proteases (such as tryptase and chymase), cytokines, and
Degranulation is also observed in neutrophils and eosinophils, though their granules contain different enzymes and antimicrobial
The process is tightly regulated to prevent excessive tissue damage. Upon activation, cells undergo structural changes,
Disruptions in degranulation regulation can lead to pathological conditions, such as anaphylaxis in severe allergic reactions