deadenylationthe
Deadenylationthe is a crucial process in eukaryotic gene regulation that involves the shortening of the poly(A) tail at the 3' end of messenger RNA (mRNA) molecules. This shortening is primarily carried out by a complex of enzymes known as deadenylases. The poly(A) tail serves as a protective cap for mRNA, preventing its degradation by exonucleases and also playing a role in translation initiation and efficiency. As the poly(A) tail shortens through deadenylation, the mRNA becomes less stable and more susceptible to degradation.
The rate of deadenylation is a key determinant of mRNA half-life, which in turn influences the amount
Beyond general mRNA turnover, deadenylation is also implicated in specific regulatory pathways. For instance, it can