ddxFy
ddxFy is a member of the DEAD‑box RNA helicase family, a group of enzymes that participate in the remodeling of RNA and ribonucleoprotein complexes through ATP‑dependent unwinding of RNA duplexes. The naming convention ddxFx indicates that it contains the conserved Asp‑Glu‑Ala‑Asp (DEAD) motif and belongs to a particular evolutionary clade of helicases.
The ddxFy protein is encoded by the ddxFy gene, which is located on chromosome 12 in humans.
Functional studies have linked ddxFy to the dynamic assembly of messenger ribonucleoprotein (mRNP) complexes. It is
Expression profiling indicates that ddxFy is ubiquitously expressed, but its transcript levels are highest in tissues
Clinically, mutations in ddxFy have been observed in a small number of patients with neurodevelopmental disorders.
Overall, ddxFy is a conserved RNA helicase that plays critical roles in RNA metabolism, ribosome assembly, and