ddimeer

Ddimeer is not a widely used term in scholarly literature and is most often encountered as a misspelling or informal variant of D-dimer, a biomarker related to clot formation and breakdown. In medical contexts, D-dimer refers to a specific fibrin degradation fragment produced when crosslinked fibrin is dissolved by plasmin, reflecting recent or ongoing coagulation and fibrinolysis.

D-dimer formation occurs when a blood clot forms and is subsequently broken down. Plasmin cleaves crosslinked fibrin, releasing D-dimer fragments into the bloodstream. The presence and level of D-dimer can therefore indicate activation of the coagulation system, though the result is not specific to a single condition.

Clinical use of D-dimer involves measurement by immunoassays, such as ELISA or latex agglutination tests. It is commonly employed to help assess suspected thrombotic events, particularly venous thromboembolism. A negative D-dimer test can help exclude thrombosis in patients with low to intermediate pretest probability, while a positive result suggests activation of coagulation and fibrinolysis but is not diagnostic on its own.

Limitations of D-dimer testing include its low specificity; many conditions—pregnancy, infection, inflammation, recent surgery or trauma, cancer, and advanced age—can elevate D-dimer levels. Consequently, results should be interpreted in the context of clinical assessment and, when indicated, followed by imaging studies.

See also: D-dimer, fibrin, coagulation, thrombosis, fibrinolysis.