checkpointsregulatory
Checkpoints regulatory refers to the mechanisms that control and monitor cell cycle checkpoints, ensuring that cells proceed through division only when conditions are favorable and all cellular processes have been correctly executed. These checkpoints act as quality control systems, preventing the propagation of damaged DNA, improper chromosome segregation, and other errors that can lead to disease.
At the core of checkpoints regulatory are proteins such as cyclin-dependent kinases (CDKs), checkpoint kinases (CHK1
The spindle assembly checkpoint, operative during metaphase, ensures that all chromosomes are properly attached to the
Regulatory checkpoints also function in response to nucleotide depletion, metabolism, and oncogenic stress. p53, in particular,
Therapeutically, many anti-cancer drugs target checkpoint regulators. For example, inhibitors of CHK1 are being explored to