centromeri
Centromeri, plural of centromere, is the region of a chromosome that forms the assembly site for the kinetochore and is essential for correct segregation during cell division. During mitosis and meiosis, spindle microtubules attach to kinetochores built on the centromeric chromatin to pull sister chromatids to opposite poles.
In most eukaryotes, centromeri are defined not by a unique DNA sequence but by specialized chromatin. The
DNA composition of centromeri varies among species. In humans, centromeric DNA is dominated by long arrays
The kinetochore is a multiprotein complex that forms on centromeric chromatin and mediates attachment to microtubules.
Centromeri function is robust but can fail, leading to aneuploidy and genomic instability observed in cancer