cchr1

CCHR1 is a term that appears in some genetic resources but does not correspond to a single widely recognized gene or protein under that exact name. In many databases, the closest well-characterized entity is CCHCR1, which stands for Coiled-Coil-Helix-Coiled-Coil-Helix Containing 1. Some sources may use cchr1 as an informal shorthand or alias, so it is important to verify the precise reference in a given dataset.

Genomic context and structure: CCHCR1 is located in the human major histocompatibility complex region on chromosome 6p21, an area rich in immune-related genes. The encoded protein contains coiled-coil motifs, a feature that often mediates protein–protein interactions and influences cytoskeletal organization. The gene comprises multiple exons and produces transcripts that can give rise to protein isoforms.

Expression and proposed function: CCHCR1 is expressed in skin and other epithelial tissues, with notable activity in keratinocytes and hair follicles. While the exact molecular function is not fully defined, the protein is thought to participate in processes related to keratinocyte differentiation and the structural biology of hair, potentially through interactions with cytoskeletal components.

Clinical and research context: Variants in the PSORS1 region, which includes CCHCR1, have been studied for associations with psoriasis susceptibility. Results across populations have been inconsistent, and the specific contribution of CCHCR1 to disease risk remains unclear. Ongoing research aims to clarify its role in skin biology and immune-related traits.

See also: CCHCR1; psoriasis susceptibility locus PSORS1; HLA region.