caspase5driven
Caspase5driven describes cellular responses predominantly mediated by caspase-5, a human inflammatory caspase homologous to murine caspase-11. In humans, caspase-5 participates in noncanonical inflammasome signaling, typically activated by cytosolic lipopolysaccharide (LPS) detection. Upon activation, caspase-5 cleaves gasdermin D, producing an N-terminal fragment that forms pores in the plasma membrane, triggering pyroptosis and the release of intracellular contents and inflammatory mediators.
In addition to pore formation, caspase-5 activity can promote downstream inflammatory signaling, including the maturation and
Regulation of caspase-5 occurs at transcriptional and post-translational levels and is influenced by innate immune signals,
Given ongoing research, the exact delineation of caspase-5–driven pathways can vary by tissue type and stimulus.