ankyrinB
Ankyrin-B, encoded by the ANK2 gene, is a cytoskeletal adaptor protein that belongs to the ankyrin family. It functions to link integral membrane proteins to the spectrin-based cytoskeleton, helping to organize and stabilize membrane protein complexes. Ankyrin-B contains an ankyrin repeat domain for binding partners, a spectrin-binding domain, and a C-terminal regulatory region. Multiple isoforms are produced by alternative splicing, with tissue-specific expression; the best characterized forms are expressed in brain and heart.
Ankyrin-B is widely expressed in neurons and cardiomyocytes and localizes to the plasma membrane, the transverse
Functionally, ankyrin-B acts as a scaffold that coordinates the trafficking, localization, and stabilization of channels and
Genetic variations in ANK2 are associated with cardiac conduction disease and arrhythmias, including ankyrin-B syndrome, which