angiotensiinikonvertaasi

Angiotensin-converting enzyme (ACE) is a zinc-dependent metallopeptidase enzyme that plays a crucial role in the renin-angiotensin system, a key component of the body's regulatory system for blood pressure and fluid balance. ACE is primarily found in the lungs, kidneys, and blood vessels. Its primary function is to convert angiotensin I, a decapeptide, into angiotensin II, an octapeptide, by removing a dipeptide (His-Leu) from the C-terminus of angiotensin I. This conversion is a critical step in the regulation of blood pressure and fluid balance.

Angiotensin II is a potent vasoconstrictor, which means it narrows blood vessels, increasing blood pressure. It also stimulates the release of aldosterone from the adrenal glands, which in turn promotes sodium reabsorption in the kidneys, leading to water retention and increased blood volume. These effects collectively contribute to the regulation of blood pressure and fluid balance in the body.

ACE inhibitors are a class of medications commonly used to treat hypertension (high blood pressure) and heart failure. These drugs work by inhibiting the activity of ACE, thereby reducing the production of angiotensin II and its associated effects. By doing so, ACE inhibitors help to lower blood pressure and improve the function of the heart and blood vessels.

The renin-angiotensin system is a complex and tightly regulated system, and ACE plays a central role in its function. Understanding the role of ACE and the renin-angiotensin system is essential for the development of effective treatments for cardiovascular diseases.