amikacins
Amikacin is a broad-spectrum antibiotic belonging to the aminoglycoside class, primarily used to treat serious bacterial infections. It was first synthesized in the 1970s and remains a key medication in clinical practice due to its effectiveness against Gram-negative bacteria, including *Pseudomonas aeruginosa*, *Escherichia coli*, and *Klebsiella pneumoniae*. Amikacin works by inhibiting bacterial protein synthesis, disrupting the formation of essential proteins necessary for bacterial survival.
The drug is typically administered intravenously or intramuscularly, as oral absorption is poor. It is often
Like other aminoglycosides, amikacin carries risks of adverse effects. The most serious include nephrotoxicity (kidney damage)
Resistance to amikacin can develop through enzymatic inactivation by bacterial enzymes or mutations in ribosomal targets.