aliskirén

Aliskiren is a medication used to treat high blood pressure, also known as hypertension. It belongs to a class of drugs called direct renin inhibitors. Renin is an enzyme produced by the kidneys that plays a crucial role in the renin-angiotensin-aldosterone system, which regulates blood pressure and fluid balance. By inhibiting renin, aliskiren effectively lowers blood pressure.

Aliskiren is typically taken orally, once a day. It can be used alone or in combination with other blood pressure medications such as diuretics, angiotensin-converting enzyme (ACE) inhibitors, or angiotensin II receptor blockers (ARBs). Its effectiveness in managing hypertension has been demonstrated in various clinical trials.

Common side effects associated with aliskiren include diarrhea, cough, and rash. More serious, though less common, side effects can include angioedema (swelling of the face, lips, tongue, or throat), kidney problems, and liver problems. Aliskiren is not recommended for use during pregnancy due to potential harm to the fetus. It is also contraindicated in patients with a history of angioedema related to ACE inhibitor or ARB therapy.

The use of aliskiren requires careful monitoring by a healthcare professional, especially to assess kidney function and blood pressure response. It is an important option in the management of hypertension, contributing to the reduction of cardiovascular risks associated with uncontrolled high blood pressure.