alfa2antiplasminiini

Alfa2antiplasminiini, also known as alpha-2-antiplasmin or alpha-2-plasmin inhibitor, is a glycoprotein that plays a crucial role in regulating the fibrinolytic system in the human body. It is a serine protease inhibitor synthesized primarily by the liver. The main function of alfa2antiplasminiini is to inhibit plasmin, the enzyme responsible for breaking down blood clots. It achieves this by binding to and inactivating plasmin, thereby preventing excessive or premature clot dissolution. This inhibitory action is essential for maintaining hemostasis and preventing bleeding disorders.

Alfa2antiplasminiini exists in circulation in two forms: free and plasmin-bound. The free form is readily available to inhibit any newly formed plasmin. The plasmin-bound form is less active. Its activity is regulated by various factors, including thrombin and specific activators. Defects in alfa2antiplasminiini can lead to an increased risk of bleeding, while elevated levels might be associated with a thrombotic tendency. Research into alfa2antiplasminiini continues to explore its potential as a therapeutic target for conditions involving abnormal blood clotting.