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adipocytokines

Adipocytokines, also known as adipokines, are cytokines produced and secreted by adipose tissue. They function as signaling molecules that convey information about the body's energy and nutritional status to other organs. They are produced by adipocytes as well as cells in the stromal vascular fraction and can act in an autocrine, paracrine, or endocrine manner.

The best known adipocytokines include leptin, which regulates appetite and energy expenditure through central nervous system

In obesity, adipose tissue expands and becomes inflamed, leading to dysregulated adipocytokine production. Adiponectin levels typically

Because adipocytokines reflect adipose tissue health and influence metabolic and immune pathways, they are actively studied

circuits;
adiponectin,
which
enhances
insulin
sensitivity
and
has
anti-inflammatory
effects;
resistin,
linked
with
insulin
resistance
in
some
contexts;
and
other
adipokines
such
as
visfatin
(NAMPT),
chemerin,
omentin,
and
apelin,
each
with
distinct
metabolic
and
inflammatory
actions.
fall
while
leptin
rises,
contributing
to
leptin
resistance
and
altered
energy
balance.
A
pro-inflammatory
milieu
and
altered
adipokine
signaling
are
associated
with
insulin
resistance,
type
2
diabetes,
and
cardiovascular
risk.
as
biomarkers
of
disease
risk
and
as
potential
targets
for
therapies
aimed
at
obesity-related
disorders.