actininteracting
Actin-interacting refers to proteins and molecules that bind to actin filaments or actin monomers to regulate the assembly, organization, and dynamics of the actin cytoskeleton. Actin-interacting proteins (ABPs) include nucleators, crosslinkers, and motors that control polymerization, filament branching, turnover, and contractility.
Nucleators such as the Arp2/3 complex and formins initiate filament formation. Elongation factors like profilin promote
Crosslinkers and bundlers such as filamin, alpha-actinin, and fascin organize filaments into networks or bundles. Myosins
Actin dynamics are regulated by signaling pathways, notably Rho family GTPases (Rho, Rac, Cdc42) that coordinate
Actin-interacting proteins are studied through biochemical assays, fluorescence and electron microscopy, and structural biology, providing insights