acetilCoAkarboxiláz
Acetyl-CoA carboxylase, often abbreviated as ACC, is a vital enzyme in the synthesis of fatty acids. It plays a crucial role in the first committed step of lipogenesis, the metabolic pathway responsible for creating fat. ACC catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, using bicarbonate as the carbon source and requiring ATP hydrolysis for energy. This reaction is highly regulated, making ACC a key control point for fatty acid synthesis in both animals and plants.
In animals, ACC exists in several isoforms, with ACC1 and ACC2 being the most prominent. ACC1 is
In plants, ACC is also essential for fatty acid synthesis, particularly in the production of seed oils.