ZeroorderAbsorption
Zero-order absorption refers to a drug absorption process in which the amount of drug entering systemic circulation per unit time remains constant, regardless of the drug concentration at the absorption site. This contrasts with first-order absorption, where the rate depends on the available amount of drug at the absorption site.
Zero-order absorption can occur when the absorption mechanism becomes saturated or when a delivery system is
Pharmacokinetic modeling of zero-order absorption often uses an input rate constant k0. In a simple one-compartment
Clinical implications include a more predictable and smoother rise in plasma concentration, which can improve exposure
Examples include some transdermal nicotine or fentanyl patches and other delivery systems designed to maintain a