ZBTB7A

ZBTB7A, also known as LRF (Leukemia/Lymphoma Related Factor) or Pokemon, is a transcription factor belonging to the POK family of zinc finger and BTB/POZ-domain proteins. The encoded protein contains an N-terminal BTB/POZ domain and multiple C2H2-type zinc finger motifs that mediate DNA binding. ZBTB7A functions primarily as a transcriptional repressor, recruiting corepressor complexes to regulate gene expression and thereby influence cellular differentiation and proliferation.

Biological roles: In mammals, ZBTB7A/LRF is important for hematopoiesis and lymphoid development. It participates in B cell lineage commitment and helps maintain lineage identity by repressing alternative fate programs; in this context it can interact with other lineage regulators to control differentiation and self-renewal. The protein is also implicated in adipocyte differentiation and other developmental processes, reflecting its broad role in gene regulation.

Clinical significance: ZBTB7A expression and activity have been linked to cancer biology. Because it can repress multiple target genes, its activity can either suppress tumor development or contribute to oncogenic programs depending on tissue context and interacting partners. Alterations in ZBTB7A expression or function have been reported in various hematologic malignancies and solid tumors, and it is studied as a potential therapeutic target or biomarker in cancer research.

Research and structure: ZBTB7A is conserved in vertebrates and studied in cell lines and animal models. Ongoing work aims to define its exact target genes, interaction networks, and context-dependent roles in development and cancer.